Divergent selection for aerobic capacity in rats as a model for complex disease.

نویسندگان

  • Lauren Gerard Koch
  • Steven Loyal Britton
چکیده

Based upon ideas about evolution, we put forth the argument that the capacity to transfer energy via aerobic metabolism is such a central feature of mammalian biology, that it must also be the primary determinant of complex disease. From this, we hypothesized that artificial selection on low and high capacity for aerobic exercise would create lines that can be used to define the divide between health and disease. In 1996 we began large-scale divergent selection for aerobic treadmill running capacity in a widely heterogeneous stock of rats (N:NIH). By ten generations we developed lines of low capacity runners (LCR) and high capacity runners (HCR) that on average differed by 317%. As a correlated trait, body mass increased at each generation in the LCR while the body mass decreased in the HCR. The lines also separated for key factors of systemic oxygen transport capacity such as maximal oxygen consumption (VO(2)max), tissue perfusion, capillary density, and oxidative enzyme activity (citrate synthase and B-HAD). We also tested our hypothesis that differences in aerobic energy transfer would produce rats that contrast for risk factors associated with complex disease. Indeed, the lines separated for cardiovascular risk factors including differences in blood pressure, cardiac contractility, visceral adiposity, plasma free fatty acids, and triglycerides. The decrease in aerobic capacity was also associated with low amounts of several proteins required for mitochondrial function.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Preconditioning Effect of Aerobic Exercise with Vitamin D3 Intake on VEGF Levels in 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Background and Objective: The purpose of this study was to investigate the preconditioning effect of aerobic exercise with vitamin D3 consumption on vascular endothelial growth factor (VEGF) level in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson’s disease. Materials and Methods: Forty-eight male rats weighing 250-300 g were randomly assigned to 6 groups: healthy control, Parkin...

متن کامل

THE EFFECT OF ENDURANCE EXERCISE TRAINING AND OCTOPAMINE SUPPLEMENTATION ON NLRP1 INFLAMMASOME, PI3K, APOPTOSIS, AND HISTOPATHOLOGICAL CHANGES IN HEART TISSUE OF RATS POISONED WITH DEEP-FRIED OIL

Background & Aims: Common nutritional mistakes cause inflammation and homeostasis disruption in heart cells. Inflammasome complex is one of the pathways that induces inflammation and degradation of cardiac protein regeneration. The aim of the present study was to investigate changes in NLRP1inflammasome, PI3k, apoptosis, and histopathology of heart tissue following aerobic physical activity and...

متن کامل

Study on the Effect of Alcoholic Extract of Flaxseed and Aerobic Exercise on Osteoporosis Parameters on Ovariectomized Rats

Background & Aims: Osteoporosis is a systemic skeletal disease associated with decreased bone mass and loss of bone tissue structure, resulting in increased susceptibility to fractures. Depending on the etiological factors, the disease may occur in primary (menopausal and aging) and secondary forms. One of the important etiologies of this disease is estrogen deficiency, in which estrogen defici...

متن کامل

Study of Aerobic Capacity and its Relationship with Lifestyle among Iranian Firefighters in an Industrial Complex

Background: Few quantitative studies in our country have been conducted to investigate the status of cardiovascular fitness in firefighters. The objective of this study was evaluation of aerobic capacity and its relation with the lifestyle of firefighters. Methods:  This study was conducted in 2014 and 165 male firefighters participated in the study. Information such as demographic data as wel...

متن کامل

Intrinsic aerobic capacity sets a divide for aging and longevity.

RATIONALE Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease. For aged populations, poor performance on treadmill or extended walking tests indicates closer proximity to future health declines. Together, these findings suggest a fundamental connection between aerobic capacity and longevity. ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Integrative and comparative biology

دوره 45 3  شماره 

صفحات  -

تاریخ انتشار 2005